Rafael Da Silva (Manchester United) vs Franck Ribery (Bayern Munich)
With Sir Alex Ferguson opting for youth before experience, Rafael will replace Gary Neville as the man to man-mark Ribery. The Frenchman was all over Neville in the first half of the first leg - running the veteran into the ground with his pace and trickery on the flank.
Rafael's stamina will give United a huge advantage, but the youngster will have to curb his penchant for going on attacking runs and leaving wide open spaces behind him.
If the past is anything to go by, Rafael hails from the Paul Scholes School of tackling - and he'll have to be very careful not to go in stabbing with his leg when Ribery is in and around the penalty box.
Michael Carrick (Manchester United) vs Mark Van Bommel (Bayern Munich)
Carrick will likely replace Scholes, who played the full 90 minutes in the first leg. The younger midfielder will be up against the highly experienced Van Bommel. The Dutchman was relatively quiet in the first leg except for one exhilarating run which culminated in Edwin van der Sar having to make a brilliant save.